Dr Alexander Fletcher
School of Mathematical and Physical Sciences
School Director of Research and Innovation
Professor of Mathematical Biology
+44 114 222 3846
Full contact details
School of Mathematical and Physical Sciences
G15
Hicks Building
Hounsfield Road
Sheffield
S3 7RH
- Profile
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- 2022 - 2024: Senior Lecturer, School of Mathematics and Statistics, University of Sheffield
- 2019 - 2022: Lecturer, School of Mathematics and Statistics, University of Sheffield
- 2015 - 2019 : Vice-Chancellor's Fellow, School of Mathematics and Statistics, University of Sheffield
- 2011 - 2015 : Research Fellow in Computational Science, Mathematical Institute, University of Oxford
- 2008 - 2015 : Stipendiary Lecturer in Mathematics, St Hugh's College, University of Oxford
- 2008 - 2011 : Postdoctoral Research Assistant, Mathematical Institute, University of Oxford
- 2005 - 2010 : DPhil, Mathematical Institute, University of Oxford
- Research interests
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I develop and apply mathematical models to study complex biological systems. Techniques range from discrete and continuous models of temporal dynamics to more computationally intensive individual-based and multiscale simulations. Major applications include mechanisms underlying tissue homeostasis and their disruption in cancer formation and progression, and the orchestration of cell-level processes such as proliferation, death, adhesion and migration to give correct tissue-level proportions in embryos.
- Publications
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Show: Featured publications All publications
Featured publications
This person does not have any publications available.
All publications
Journal articles
- . PLOS Computational Biology, 20(4), e1012001-e1012001.
- . Biology Open, 12(9).
- . PLOS Computational Biology, 19(8).
- . Molecular Biology of the Cell, 34(8), ar81.
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- . GigaScience, 11(2022).
- . PLoS Computational Biology, 18(1).
- . eLife, 10.
- . Frontiers in Endocrinology, 12.
- . WIREs Mechanisms of Disease.
- . Philosophical Transactions of the Royal Society B: Biological Sciences, 375(1809).
- . Philosophical Transactions of the Royal Society B: Biological Sciences, 375(1809).
- . Frontiers in Bioengineering and Biotechnology, 8.
- . Physical Biology.
- . Journal of Open Source Software, 5(47), 1848-1848.
- . Bulletin of Mathematical Biology, 82(2).
- . Computational and Structural Biotechnology Journal, 18, 230-240.
- . PLOS Biology, 17(12).
- . EvoDevo, 10(1).
- . Systematic Biology, 0, 1-41.
- . Seminars in Cell and Developmental Biology, 93, 46-54.
- . iScience, 17, 49-66.
- . Cell Reports, 27(8), 2524-2524.
- . Current Stem Cell Reports, 5(1), 22-30.
- . Cell Death & Disease, 10.
- . EMBO Journal, 38(3).
- . Science Advances, 4(11).
- . Interface, 15(145).
- . Journal of Mathematical Biology, 76(7), 1673-1697.
- . Journal of Theoretical Biology, 443, 66-81.
- . SIAM Journal on Scientific Computing, 39(5), B943-B967.
- . Current Opinion in Systems Biology, 5, 41-49.
- . Journal of Computational Physics, 345, 752-767.
- . PLoS Computational Biology, 13(7).
- . Frontiers in Plant Science, 8.
- . Philosophical Transactions of the Royal Society B: Biological Sciences, 372(1720).
- . PLoS Computational Biology, 13(2).
- . npj Systems Biology and Applications, 3(1).
- . Interface, 13(124).
- . eLife, 5.
- . Cancer Prevention Research, 9(4), 283-295.
- . Mathematical Models and Methods in Applied Sciences, 25(13), 2563-2585.
- . Nature Communications, 6(1).
- . PLoS Computational Biology, 11(9).
- . Computer Physics Communications, 192, 130-137.
- . Mathematical Biosciences and Engineering, 12(6), 1321-1340.
- . Royal Society Open Science, 1(1), 140080-140080.
- . Cell Reports, 8(4), 940-947.
- . Journal of The Royal Society Interface, 11(97), 20140320-20140320.
- . Biophysical Journal, 106(11), 2291-2304.
- . Cell Biochemistry and Biophysics, 68(3), 615-628.
- . European Journal of Cancer, 50(17), 3068-3075.
- . Progress in Biophysics and Molecular Biology, 113(2), 299-326.
- . Nature Reviews Molecular Cell Biology, 14(9), 581-591.
- . Journal of the Royal Society Interface, 10(85).
- . Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 5(4), 391-407.
- . Journal of Theoretical Biology, 312, 143-156.
- . Current Biology, 22(18), 1699-1704.
- . Journal of Theoretical Biology, 300, 118-133.
- . Journal of Theoretical Biology, 298, 82-91.
- . Physical Biology, 8(2), 026011-026011.
- . Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 368(1930), 5013-5028.
- . Cell Proliferation, 42(5), 617-636.
- . Computer Physics Communications, 180(12), 2452-2471.
- . Development.
- . PLOS Computational Biology, 12(1), e1004712-e1004712.
- . PLOS Computational Biology, 11(12), e1004679-e1004679.
- . Physical Biology, 12(5), 056005-056005.
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- . PLOS Computational Biology, 11(4), e1004214-e1004214.
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- . PLoS Computational Biology, 10(3), e1003506-e1003506.
- . PLoS Computational Biology, 9(10), e1003276-e1003276.
- . PLoS Computational Biology, 9(3), e1002970-e1002970.
- . Physical Biology, 6(3), 036001-036001.
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- . FASEB Journal.
Chapters
Conference proceedings papers
- A multidisciplinary approach to studying crypt-villus homeostasis and regeneration in the intestinal epithelium. FEBS JOURNAL, Vol. 281 (pp 217-218)
Preprints
- , Cold Spring Harbor Laboratory.
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- , Cold Spring Harbor Laboratory.
- , MDPI AG.
- , MDPI AG.
- Coupled differentiation and division of embryonic stem cells inferred from clonal snapshots, arXiv.
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- , Cold Spring Harbor Laboratory.
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- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- , Cold Spring Harbor Laboratory.
- Research group
- Grants
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Current grants, as Principal Investigator: Inferring epithelial tissue mechanics through data-efficient multi-fidelity modelling BBSRC Understanding self-organised tissue patterning across scales EPSRC Chaste: developing sustainable software for computational biology BBSRC Current grants, as Coinvestigator: Hypothalamic development from self-organising progenitors Wellcome Trust Past grants, as Coinvestigator: How do the atypical cadherins Fat and Dachsous integrate growth and patterning during development? BBSRC
- Teaching activities
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MAS116 Mathematical Investigation Skills
MAS2007 Mathematics and Statistics in Action
Links