Motor Neuron Disease Appeal

Â鶹ֱ²¥app has some of the best minds in the world working on MND (ALS) research. When you make a gift you'll bring hope to people suffering from the world's cruellest disease.

How you can help

Professor Chris McDermott
Professor Chris McDermott
Make your gift today 
Big Walk 2022 walker
Take on the Big Walk 2025 for MND 

The impact of your support

Gemma in her mobility aid with a tracheostomy tube in her neck
Gemma needed a tracheostomy tube to help suction saliva so she could breathe

Your gift will bring hope to families coping with MND

A passionate supporter of MND research at Sheffield, Gemma sadly lost her battle with MND in 2023. Helping SITraN find a cure for MND means so much to her parents Nigel and Sharon.

Read Gemma's story

SITraN staff taking on the Big Walk

We won't stop until we find a cure

MND kills six people in the UK every day, with a third of those diagnosed losing their lives within just a year. But Sheffield research is leading the way and providing new hope.

How new treatments will be made in Sheffield

Making MND history

How do you treat the 'cruellest disease'?

There is currently no cure for motor neuron disease. But there is hope. Sheffield researchers are working to make MND history.

Find out more

Research breakthroughs

Parkinson's researcher in a lab
10 years of impact 
head up collar
Head Up collar 
Photo of a surgeon talking to a patient in a hospital bed
A landmark clinical trial 

Sheffield's leading research talent

Pam Shaw in front of SITraN

Professor Dame Pamela Shaw

Professor Dame Pamela Shaw has been a pioneer in MND research and has dedicated her career to understanding and treating this devastating condition.

Find out more

Professor McDermott standing next to the HeadUp Collar
Professor Chris McDermott and the award winning HeadUp Collar

Professor Chris McDermott

Professor Chris McDermott and his team work closely with people with MND to develop therapies that transform the lives of patients by giving them some independence back.

Find out more

SITraN: a global centre for excellence

  • Opened by Queen Elizabeth II in 2010, SITraN is a leading global facility at the forefront of research for neurodegenerative diseases.
  • Successfully led 250 clinical studies to improve our understanding of neurological diseases and create new treatments.
  • Pioneered the development of 'Tofersen' for people with a genetic form of MND, a global breakthrough and turning point in MND treatment.