Professor Chris Toseland
Clinical Medicine, School of Medicine and Population Health
Professor of Cancer Biophysics
+44 114 215 9080
Full contact details
Clinical Medicine, School of Medicine and Population Health
FU34, F Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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For enquiries please contact - ClinMed-Operational@sheffield.ac.uk
2019: Senior Lecturer/MRC Career Development Award Fellowship
School of Medicine & Population Health - University of Sheffield
2015 - 2019: MRC Career Development Award
Schools of Biosciences - University of Kent
April 2015: Leverhulme Early Career Research Fellow
Schools of Biosciences - University of Kent
2013 – 2015: Senior Post-Doc Researcher
Max-Planck Institute for Biochemistry, Munich, Germany
2010 – 2013: EMBO Long Term Fellow
LMU Munich, Munich, Germany
2009 – 2010: Post-Doctoral Research Associate
MRC National Institute for Medical Research, London, UK
2006 – 2009: PhD
MRC National Institute for Medical Research, London, UK
2002 – 2006: BSc Biochemistry
University of Wales - Aberystwyth
- Research interests
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The lab specialises in application of fluorescence and mechanical measurements from whole cells to single molecules. We are a multidisciplinary lab drawing upon core techniques in Cell Biology, Biochemistry, Biophysics, Mechanobiology, Super Resolution single molecule imaging and Genomics Gene expression, the transfer of the genetic code into cellular proteins is one of the most fundamental processes in living cells. This process is orchestrated by RNA polymerases, which are highly regulated to ensure correct expression.
A breakdown in this regulation leads to development disabilities and most notably cancer formation. Furthermore, changes in expression control embryonic development and stem cell differentiation.
Over the past decade it has become established that myosin motors are present in the nucleus and function in transcription, but what role they play in the organisation and transcription of genetic information is unclear.
For the first time we combine classical biochemical and single molecule assays to provide a quantitative high-resolution description of the activity of these nuclear myosins; providing a mechanistic insight into the activity of these proteins.
Please see External Lab HomePage for more information.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
All publications
Journal articles
- . Biochemical Journal, 479(13), 1409-1428.
- . Nature Communications, 13(1).
- . Methods Mol Biol, 2476, 171-181.
- . Methods Mol Biol, 2476, 293-309.
- . International Journal of Molecular Sciences, 22(6).
- . Biomolecules, 11(2).
- . Biophysical Journal.
- . Nucleic Acids Research, 49(1), 340-353.
- . The Journal of Biochemistry.
- . Journal of Cell Science, 133(11), jcs242420-jcs242420.
- . Journal of Biological Chemistry.
- . eLife, 2019(8).
- . Biochemical and Biophysical Research Communications, 496(3), 820-825.
- . Nature Communications, 8.
- . Impact, 2017(10), 49-51.
- . Scientific Reports, 7.
- . Nature Communications, 7.
- . Nucleic Acids Research, 43(7), 3841-3856.
- . Molecular Cell, 57(2), 290-303.
- , 49-65.
- , 1-24.
- , 67-86.
- . Journal of Biological Chemistry, 288(35), 25183-25193.
- . Nucleic Acids Research, 41(9), 5010-5023.
- . Journal of Chemical Biology, 6(3), 85-95.
- . Journal of Biological Chemistry, 287(33), 27556-27566.
- . Biophysical Journal, 102(3), 570a-570a.
- , 161-174.
- , 193-214.
- . Nucleic Acids Research, 38(13), 4448-4457.
- . Methods, 51(3), 259-268.
- . Journal of Molecular Biology, 392(4), 1020-1032.
- . Expert Opinion on Drug Discovery, 2(1), 19-35.
- Alpha helical trans-membrane proteins: Enhanced prediction using a Bayesian approach.. Bioinformation, 1(6), 234-236.
- A predictor of membrane class: Discriminating alpha-helical and beta-barrel membrane proteins from non-membranous proteins.. Bioinformation, 1(6), 208-213.
- Beta barrel trans-membrane proteins: Enhanced prediction using a Bayesian approach.. Bioinformation, 1(6), 231-233.
- . ChemInform, 37(31).
- . BMC Biochemistry, 7(1), 18-18.
- . Journal of Chemical Information and Modeling, 46(3), 1491-1502.
- . Nucleic Acids Research, 34(90001), D199-D203.
- . BMC Bioinformatics, 6(1), 283-283.
- . Immunome Research, 1(1), 4-4.
- . Current Computer Aided-Drug Design, 1(4), 377-395.
- . Biochemical Society Transactions.
- Autophagy receptor NDP52 alters DNA conformation to modulate RNA Polymerase II transcription. Nature Communications.
- . International Journal of Molecular Sciences, 21(1), 67-67.
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- . eLife, 4.
- . PLoS ONE, 7(6), e38270-e38270.
- . Bioinformation, 1(5), 184-187.
- . Bioinformation, 1(5), 176-179.
- Magnetic Tweezers in a Microplate Format. Journal of Visualized Experiments.
Chapters
- , Encyclopedia of Biophysics (pp. 950-958). Springer Berlin Heidelberg
- , Single Molecule Enzymology (pp. E1-E1). Humana Press
- , In Silico Immunology (pp. 139-175). Springer US
Conference proceedings papers
- . Biophysical Journal, Vol. 116(3) (pp 77a-77a)
- . Biophysical Journal, Vol. 116(3) (pp 210a-210a)
- . Biophysical Journal, Vol. 116(3) (pp 178a-178a)
- . Biophysical Journal, Vol. 116(3) (pp 260a-260a)
- . Biophysical Journal, Vol. 116(3) (pp 208a-209a)
- . Biophysical Journal, Vol. 116(3) (pp 209a-209a)
- Activation of nuclear myosin VI leads to enhanced gene expression.. MOLECULAR BIOLOGY OF THE CELL, Vol. 27
- Dissecting the role of Myosin VI in the nucleus.. MOLECULAR BIOLOGY OF THE CELL, Vol. 27
- . Biophysical Journal, Vol. 102(3) (pp 569a-569a)
- . Biophysical Journal, Vol. 100(3) (pp 116a-116a)
- . Biophysical Journal, Vol. 100(3) (pp 72a-73a)
- . Biophysical Journal, Vol. 96(3) (pp 415a-415a)
Preprints
- Research group
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- Dr Natalia Fili (Postdoctoral Research Associate)
- Rosemarie Gough (Postdoctoral Research Associate)
- Alexander Cook (Postdoctoral Research Associate)
- Alia dos Santos (PhD Student)
- Grants
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- Medical Research Council
- Cancer Research UK
- Science and Technology Facilities Council
- Royal Society
- Leverhulme Trust